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KMID : 1149220040120020109
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Korean Journal of Oriental Medical Prescription
2004 Volume.12 No. 2 p.109 ~ p.117
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Hepatoprotective and antifibrotic effects of extracts from Persicae Semen
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Na Ji-Xing
Park Eun-Jeon
Sohn Dong-Hwan
Ko Geon-Il
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Abstract
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This study was carried out to investigate the liver protective effects of extracts from Persicae Semen (WT-003, WT-005, WT-006). The acute hepatic injury was induced by intraperitoneal injection of alpha-naphtylisothiocyanate (75 mg/kg, p.o.) and treated with WT-006 (100 mg/kg/day, 200 mg/kg/day, 400 mg/kg/day). The experimental hepatic fibrosis was induced by bile duct ligation／scission(BDL/S), duration of 4 weeks and treated with WT-003, WT-005 or WT-006 (200 mg/kg/days for 4 week). In acute liver injury, WT-006 (200 or 400 mg/kg) lowered serum alanine transferase(ALT) and aspartate transferase(AST) significantly. In fibrotic rats, WT-006 treatment inhibited the hydroxyproline deposition in liver and lowered serum AST, ALT and ALP, significantly. These results suggest WT-006 extract, which does not contain amygdalin, from Persicae Semen have liver protective and antifibrotic effects in rats.
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KEYWORD
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Persicae Semen, liver, alpha-naphtylisothiocyanate, bile duct ligation/scission
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